Scientia Naturalis Letters focuses on advancing multidisciplinary research that bridges the natural sciences with computational, experimental, and applied approaches. The journal welcomes contributions that are scientifically robust, innovative, and relevant to both specialized and interdisciplinary audiences.

The journal provides a forum for scholarly communication in the following key areas:

1. Mathematical and Statistical Sciences, including computational mathematics, control systems, numerical modeling, algebra, topology, probability theory, and financial mathematics.
2. Computer and Information Sciences, covering artificial intelligence, machine learning, cybersecurity, blockchain, data science, network systems, and Internet of Things (IoT).
3. Physical and Chemical Sciences, encompassing quantum and classical physics, materials chemistry, catalysis, spectroscopy, nanotechnology, and environmental and green chemistry.
4. Biological and Environmental Sciences, addressing molecular biology, genetics, ecology, biodiversity, environmental management, sustainability, and climate science.
5. Natural Products and Pharmaceutical Sciences, focusing on phytochemistry, marine natural products, biosynthetic pathways, pharmacology, drug development, formulation science, and biomedical applications.

Types of articles accepted include original research papers, systematic and narrative reviews, brief reports, technical notes, empirical studies, case studies, and conceptual frameworks. The journal particularly encourages submissions that demonstrate interdisciplinary insight, methodological innovation, or address complex real-world problems.