Scientia Naturalis Letters focuses on advancing multidisciplinary research that bridges the natural sciences with computational, experimental, and applied approaches. The journal welcomes contributions that are scientifically robust, innovative, and relevant to both specialized and interdisciplinary audiences.

The journal provides a forum for scholarly communication in the following key areas:

1. Physical and Chemical Sciences, covering a broad range of topics including quantum and classical physics, materials science, catalysis, spectroscopy, nanotechnology, analytical chemistry, environmental chemistry, and green chemistry innovations.
2. Biological and Life Science, encompassing research in molecular biology, genetics, microbiology, ecology, biodiversity, conservation, sustainability science, and climate change studies.
3. Earth System and Environmental Studies, focusing on geosciences, atmospheric sciences, hydrology, soil science, oceanography, environmental monitoring, environmental monitoring, and integrated earth system modeling.
4. Natural Products and Bioactive Compounds, highlighting the discovery, phytochemistry, characterization, and biological evaluation of natural products from terrestrial and marine sources, including structure elucidation, biosynthesis, and potential applications in health and agriculture.
5. Pharmaceutical and Biomedical Sciences, featuring research in biosynthetic pathways, drug discovery and development, pharmacology, pharmaceutical formulation, nanomedicine, and biomedical technologies.

Types of articles accepted include original research papers, systematic and narrative reviews, brief reports, technical notes, empirical studies, case studies, and conceptual frameworks. The journal particularly encourages submissions that demonstrate interdisciplinary insight, methodological innovation, or address complex real-world problems.